NCBI My Bibliography: https://www.ncbi.nlm.nih.gov/myncbi/jihoon.lee.3/bibliography/public/
Google Scholar: https://scholar.google.com/citations?user=iMJwovQAAAAJ&hl=en
*: Equal contribution; ^: corresponding author(s)
1. Lee. J.H.*^, Tingey, M.*, Zhang, Z.*, Buerger, F., Hong, J., Zhang, G., Yang, M., Du, B., Jeong, J., Tamayo, I., Zhao, Q., Hildebrandt, F., Yang, W.^, Xu, K.^. (2025) N6-adenosine methylation enhances nuclear mRNA export via the METTL3-NUP93 interaction. (Accepted in Nat Cell Biol.)
2. Sui, P.*, Li, Y. *, Hong, J., Delma, C.R., Chen, S., Wang, J., Zhang, P., Han S., Noor, A., Yang, H., Pang, Y., Xu, M., Lee, J.H., Yang, F.#. (2026) Depletion of EvC Ciliary Complex Subunit 1/2 eradicates a subset of acute myeloid leukemia. Leukemia 40(1):166-177. doi: 10.1038/s41375-025-02803-3.
3. Guo, Y.*, Sui, P.*, Yang, H.*, Zhu, G., Zhao, Y., Li, Y., Chen, S., Delma, C.R., Ge, G., Eisa, Y. A., Medina, E.A., Zhang, P., Lee, J.H., Xu, M., Yang, F.#. (2026) Phf6 truncating mutation engenders leukemogenesis in mice. Leukemia doi.org/10.1038/s41375-025-02828-8
4. Jeong, J., John A.K., Lee, J.H.^. (2025) O-GlcNAcylation Locks the m6A-SRSF1-MCL1 axis in Myeloid Malignancies. Molecular Therapy 33;12, https://doi.org/10.1016/j.ymthe.2025.10.060 (Commentary)
5. Hong, J.*, Sui, P.*, Li, Y., Xu, K.Y., Lee, J.H., Chen, S., Wang, J., Zhang, P., Wingate, N., Yuan, Y., Hromas, R., Zhou, H., Hamamoto, K., Su, R., Chen, J., Huang, S., Zhou, D., You, J.M., Yang, F.#, Wang, J.#, Xu, M.#. (2025) PSPC1 exerts an oncogenic role in AML by regulating a leukemic transcription program in cooperation with PU.1. Cell Stem Cell. 6;32(3):463-478.e6. doi: 10.1016/j.stem.2025.01.010
6. Jeong, J., John, K., Hong, J., Lee, J.H.^. Heterogeneous nuclear ribonucleoprotein A2/B1, a key regulator of myocardial fibrosis. Clin Transl Dis. 2024 Mar;14(3):e1616. doi: 10.1002/ctd2.319. (Commentary)
7. Hong, J.*, Lee, J.H.*, Zhang, Z.*, Wu, Y., Yang, M., Liao, Y., De la Rosa, R., Scheirer, J., Pechacek, D., Zhang, N., Xu, Z., Curiel, T., Tan, X., Huang, T.H., Xu, K.^. (2022) PRC2-Mediated Epigenetic Suppression of Type I IFN-STAT2 Signaling Impairs Antitumor Immunity in Luminal Breast Cancer. Cancer Res. 82(24):4624-4640. doi: 10.1158/0008-5472.
8. Hong, J., Xu, K., Lee, J.H.^. (2022) Biological roles of the RNA m6A modification and its implications in cancer. Exp Mol Med.54(11):1822-1832. doi: 10.1038/s12276-022-00897-8. (Review article)
9. Liao, Y.*, Chen, C.H.*, Xiao, T., de la Peña Avalos, B., Dray, E.V., Cai, C., Gao, S., Shah, N., Zhang, Z., Feit, A., Xue, P., Liu, Z., Yang, M., Lee, J.H., Xu, H., Li, W., Mei, S., Pierre, R.S., Shu, S., Fei, T., Duarte, M., Zhao, J., Bradner, J.E., Polyak, K., Kantoff, P.W., Long, H., Balk, S.P., Liu, X.S.^, Brown, M.^, Xu, K.^. (2022) Inhibition of EZH2 transactivation function sensitizes solid tumors to genotoxic stress. Proc Natl Acad Sci U S A. 119(3). doi: 10.1073/pnas.2105898119.
10. Lee, J.H.*, Hong, J.*, Zhang, Z.*, de la Peña Avalos, B., Proietti, C.J., Deamicis, A.R., Guzmán, G. P., Lam, HM., Garcia, J., Roudier, M.P., Sisk, A.E., De La Rosa, R., Vu, K., Yang, M., Liao, Y., Scheirer, J., Pechacek, D., Yadav, P., Rao, M.K., Zheng, S., Johnson-Pais, T.L., Leach, R.J., Elizalde, P.V., Dray, E., Xu, K.^. (2021) Regulation of telomere homeostasis and genomic stability in cancer by N6-adenosine methylation (m6A). Sci Adv. 7(31). doi: 10.1126/sciadv.abg7073.
11. Yang, M.*, Lee, J.H.*, Zhang, Z.*, De La Rosa, R., Bi, M., Tan, Y., Liao, Y., Hong, J., Du, B., Wu, Y., Scheirer, J., Hong, T., Li, W., Fei, T., Hsieh, C.L., Liu, Z., Li, W., Rosenfeld, M.G., Xu, K.^. (2020) Enhancer RNAs Mediate Estrogen-Induced Decommissioning of Selective Enhancers by Recruiting ERα and Its Cofactor. Cell Rep. 31(12):107803. doi: 10.1016/j.celrep.2020.107803.
12. Rahnamoun, H., Hong, J., Sun, Z., Lee, J.H., Lu, H., Lauberth, S.M.^. (2018) Mutant p53 regulates enhancer-associated H3K4 monomethylation through interactions with the methyltransferase MLL4. J Biol Chem. 293(34):13234-13246. doi: 10.1074/jbc.RA118.003387.
13. Rahnamoun, H., Lee, J.H., Sun, Z., Lu, H., Ramsey, K.M., Komives, E.A., Lauberth, S.M.^. (2018) RNAs interact with BRD4 to promote enhanced chromatin engagement and transcription activation. Nat Struct Mol Biol. 25(8):687-697. doi: 10.1038/s41594-018-0102-0.
14. Lee, J.H., Jung, M., Hong, J., Kim, M.K., Chung, I.K.^. (2018) Loss of RNA-binding protein HuR facilitates cellular senescence through posttranscriptional regulation of TIN2 mRNA. Nucleic Acids Res. 46(8):4271-4285. doi: 10.1093/nar/gky223.
15. Hong, J., Lee, J.H., Chung, I.K.^. (2016) Telomerase activates transcription of cyclin D1 gene through an interaction with NOL1. J Cell Sci. 129(8):1566-79. doi: 10.1242/jcs.181040.
16. Lee, J.H., Jeong, S.A., Khadka, P., Hong, J., Chung, I.K.^. (2015) Involvement of SRSF11 in cell cycle-specific recruitment of telomerase to telomeres at nuclear speckles. Nucleic Acids Res. 43(17):8435-51. doi: 10.1093/nar/gkv844.
17. Jeong, S.A.*, Kim, K.*, Lee, J.H., Cha, J.S., Khadka, P., Cho, H.S.^, Chung, I.K.^. (2015) Akt-mediated phosphorylation increases the binding affinity of hTERT for importin α to promote nuclear translocation. J Cell Sci. 128(12):2287-301. doi: 10.1242/jcs.166132.
18. Khadka, P.*, Lee, J.H.*, Baek, S.H., Oh, S.Y., Chung, I.K.^. (2014) DNA-PKcs-interacting protein KIP binding to TRF2 is required for the maintenance of functional telomeres. Biochem J. 463(1):19-30. doi: 10.1042/BJ20131395.
19. Lee, J.H., Lee, Y.S., Jeong, S.A., Khadka, P., Roth, J., Chung, I.K.^. (2014) Catalytically active telomerase holoenzyme is assembled in the dense fibrillar component of the nucleolus during S phase. Histochem Cell Biol. 141(2):137-52. doi: 10.1007/s00418-013-1166-x.
20. Lee, J.H., Khadka, P., Baek, S.H., Chung, I.K.^. (2010) CHIP promotes human telomerase reverse transcriptase degradation and negatively regulates telomerase activity. J Biol Chem. 285(53):42033-45. doi: 10.1074/jbc.M110.149831.
21. Lee, J.H., Chung, I.K.^. (2010) Curcumin inhibits nuclear localization of telomerase by dissociating the Hsp90 co-chaperone p23 from hTERT. Cancer Lett. 290(1):76-86. doi: 10.1016/j.canlet.2009.08.026.
2. Sui, P.*, Li, Y. *, Hong, J., Delma, C.R., Chen, S., Wang, J., Zhang, P., Han S., Noor, A., Yang, H., Pang, Y., Xu, M., Lee, J.H., Yang, F.#. (2026) Depletion of EvC Ciliary Complex Subunit 1/2 eradicates a subset of acute myeloid leukemia. Leukemia 40(1):166-177. doi: 10.1038/s41375-025-02803-3.
3. Guo, Y.*, Sui, P.*, Yang, H.*, Zhu, G., Zhao, Y., Li, Y., Chen, S., Delma, C.R., Ge, G., Eisa, Y. A., Medina, E.A., Zhang, P., Lee, J.H., Xu, M., Yang, F.#. (2026) Phf6 truncating mutation engenders leukemogenesis in mice. Leukemia doi.org/10.1038/s41375-025-02828-8
4. Jeong, J., John A.K., Lee, J.H.^. (2025) O-GlcNAcylation Locks the m6A-SRSF1-MCL1 axis in Myeloid Malignancies. Molecular Therapy 33;12, https://doi.org/10.1016/j.ymthe.2025.10.060 (Commentary)
5. Hong, J.*, Sui, P.*, Li, Y., Xu, K.Y., Lee, J.H., Chen, S., Wang, J., Zhang, P., Wingate, N., Yuan, Y., Hromas, R., Zhou, H., Hamamoto, K., Su, R., Chen, J., Huang, S., Zhou, D., You, J.M., Yang, F.#, Wang, J.#, Xu, M.#. (2025) PSPC1 exerts an oncogenic role in AML by regulating a leukemic transcription program in cooperation with PU.1. Cell Stem Cell. 6;32(3):463-478.e6. doi: 10.1016/j.stem.2025.01.010
6. Jeong, J., John, K., Hong, J., Lee, J.H.^. Heterogeneous nuclear ribonucleoprotein A2/B1, a key regulator of myocardial fibrosis. Clin Transl Dis. 2024 Mar;14(3):e1616. doi: 10.1002/ctd2.319. (Commentary)
7. Hong, J.*, Lee, J.H.*, Zhang, Z.*, Wu, Y., Yang, M., Liao, Y., De la Rosa, R., Scheirer, J., Pechacek, D., Zhang, N., Xu, Z., Curiel, T., Tan, X., Huang, T.H., Xu, K.^. (2022) PRC2-Mediated Epigenetic Suppression of Type I IFN-STAT2 Signaling Impairs Antitumor Immunity in Luminal Breast Cancer. Cancer Res. 82(24):4624-4640. doi: 10.1158/0008-5472.
8. Hong, J., Xu, K., Lee, J.H.^. (2022) Biological roles of the RNA m6A modification and its implications in cancer. Exp Mol Med.54(11):1822-1832. doi: 10.1038/s12276-022-00897-8. (Review article)
9. Liao, Y.*, Chen, C.H.*, Xiao, T., de la Peña Avalos, B., Dray, E.V., Cai, C., Gao, S., Shah, N., Zhang, Z., Feit, A., Xue, P., Liu, Z., Yang, M., Lee, J.H., Xu, H., Li, W., Mei, S., Pierre, R.S., Shu, S., Fei, T., Duarte, M., Zhao, J., Bradner, J.E., Polyak, K., Kantoff, P.W., Long, H., Balk, S.P., Liu, X.S.^, Brown, M.^, Xu, K.^. (2022) Inhibition of EZH2 transactivation function sensitizes solid tumors to genotoxic stress. Proc Natl Acad Sci U S A. 119(3). doi: 10.1073/pnas.2105898119.
10. Lee, J.H.*, Hong, J.*, Zhang, Z.*, de la Peña Avalos, B., Proietti, C.J., Deamicis, A.R., Guzmán, G. P., Lam, HM., Garcia, J., Roudier, M.P., Sisk, A.E., De La Rosa, R., Vu, K., Yang, M., Liao, Y., Scheirer, J., Pechacek, D., Yadav, P., Rao, M.K., Zheng, S., Johnson-Pais, T.L., Leach, R.J., Elizalde, P.V., Dray, E., Xu, K.^. (2021) Regulation of telomere homeostasis and genomic stability in cancer by N6-adenosine methylation (m6A). Sci Adv. 7(31). doi: 10.1126/sciadv.abg7073.
11. Yang, M.*, Lee, J.H.*, Zhang, Z.*, De La Rosa, R., Bi, M., Tan, Y., Liao, Y., Hong, J., Du, B., Wu, Y., Scheirer, J., Hong, T., Li, W., Fei, T., Hsieh, C.L., Liu, Z., Li, W., Rosenfeld, M.G., Xu, K.^. (2020) Enhancer RNAs Mediate Estrogen-Induced Decommissioning of Selective Enhancers by Recruiting ERα and Its Cofactor. Cell Rep. 31(12):107803. doi: 10.1016/j.celrep.2020.107803.
12. Rahnamoun, H., Hong, J., Sun, Z., Lee, J.H., Lu, H., Lauberth, S.M.^. (2018) Mutant p53 regulates enhancer-associated H3K4 monomethylation through interactions with the methyltransferase MLL4. J Biol Chem. 293(34):13234-13246. doi: 10.1074/jbc.RA118.003387.
13. Rahnamoun, H., Lee, J.H., Sun, Z., Lu, H., Ramsey, K.M., Komives, E.A., Lauberth, S.M.^. (2018) RNAs interact with BRD4 to promote enhanced chromatin engagement and transcription activation. Nat Struct Mol Biol. 25(8):687-697. doi: 10.1038/s41594-018-0102-0.
14. Lee, J.H., Jung, M., Hong, J., Kim, M.K., Chung, I.K.^. (2018) Loss of RNA-binding protein HuR facilitates cellular senescence through posttranscriptional regulation of TIN2 mRNA. Nucleic Acids Res. 46(8):4271-4285. doi: 10.1093/nar/gky223.
15. Hong, J., Lee, J.H., Chung, I.K.^. (2016) Telomerase activates transcription of cyclin D1 gene through an interaction with NOL1. J Cell Sci. 129(8):1566-79. doi: 10.1242/jcs.181040.
16. Lee, J.H., Jeong, S.A., Khadka, P., Hong, J., Chung, I.K.^. (2015) Involvement of SRSF11 in cell cycle-specific recruitment of telomerase to telomeres at nuclear speckles. Nucleic Acids Res. 43(17):8435-51. doi: 10.1093/nar/gkv844.
17. Jeong, S.A.*, Kim, K.*, Lee, J.H., Cha, J.S., Khadka, P., Cho, H.S.^, Chung, I.K.^. (2015) Akt-mediated phosphorylation increases the binding affinity of hTERT for importin α to promote nuclear translocation. J Cell Sci. 128(12):2287-301. doi: 10.1242/jcs.166132.
18. Khadka, P.*, Lee, J.H.*, Baek, S.H., Oh, S.Y., Chung, I.K.^. (2014) DNA-PKcs-interacting protein KIP binding to TRF2 is required for the maintenance of functional telomeres. Biochem J. 463(1):19-30. doi: 10.1042/BJ20131395.
19. Lee, J.H., Lee, Y.S., Jeong, S.A., Khadka, P., Roth, J., Chung, I.K.^. (2014) Catalytically active telomerase holoenzyme is assembled in the dense fibrillar component of the nucleolus during S phase. Histochem Cell Biol. 141(2):137-52. doi: 10.1007/s00418-013-1166-x.
20. Lee, J.H., Khadka, P., Baek, S.H., Chung, I.K.^. (2010) CHIP promotes human telomerase reverse transcriptase degradation and negatively regulates telomerase activity. J Biol Chem. 285(53):42033-45. doi: 10.1074/jbc.M110.149831.
21. Lee, J.H., Chung, I.K.^. (2010) Curcumin inhibits nuclear localization of telomerase by dissociating the Hsp90 co-chaperone p23 from hTERT. Cancer Lett. 290(1):76-86. doi: 10.1016/j.canlet.2009.08.026.
